This partnership combines Indena’s expertise in developing and producing highly potent payloads with TCG GreenChem’s advanced approaches in green chemistry, catalysis and biocatalysis ... and "right first time" methodologies.
Indena is an Italian global leader in the development and production of high-quality active pharmaceutical ingredients (APIs) and highly potent APIs (HPAPIs) obtained by plant extraction, synthesis and precision fermentation.
Indena’s unique ability to handle high-containment development and production makes Indena a significant player in the field of payloads for ADCs.
Based in Princeton (NJ, US), TCG GreenChem is a technology and science-driven innovative CRDMO (contract research, development and manufacturing organisation) focused on the rapid development of pharmaceutical processes utilising catalysis, flow chemistry, biocatalysis and data-driven design.
By combining complementary capabilities — including high containment knowledge and rapid process R&D — the two companies aim to provide ADC developers with faster, more efficient, and reliable routes to clinical and commercial supply.
The first milestone of this co-operation focuses on a novel payload–linker designed to showcase how this integrated approach can reduce development timelines and improve delivery to patients.
Daniele Giavini, Managing Director at Indena, comments: “Partnering with TCG GreenChem means working with an authoritative partner to address the needs of ADCs developers."
"Our expertise in high containment processes, designed to produce innovative HPAPIs, complements their deep capability in complex chemistry and process intensification, managed with a green approach."
"With this approach, we will be able to offer next-generation solutions to the industry while always keeping sustainability in mind. I am confident we will make a significant impact when it comes to the development of precision treatments ".
Chris Senanayake, CEO of TCG GreenChem, states: "We are proud to join forces with Indena, a recognised pioneer and leader in highly potent and oncological API chemistry."
"Together, we will drive a new era of greener, faster and more flexible pharmaceutical development that aligns with the industry’s evolving expectations."
This partnership addresses the sharp surge in pipeline activity throughout the pharmaceutical industry because of continuous increases in both commercial and clinical ADCs.
As of mid-2025, more than 180 companies are actively developing more than 1170 ADC candidates. This rapid growth places significant demands on development and manufacturing infrastructure, requiring greater capacity and faster timelines while maintaining the highest quality standards.
Indeed, TCG GreenChem works on complex chemistry, reducing environmental impact via solvent minimisation, waste reduction and energy efficient reactions.
Indena's comprehensive sustainability programme, in alignment with the United Nations' 2030 Agenda for Sustainable Development Goals (SDGs), addresses sustainable sourcing, advanced energy utilisation through renewable sources, product design focused on waste reduction, the minimisation of resource consumption and an overarching commitment to the circular economy.
This collaboration is also set to translate into a tangible impact on patients' lives, accelerating the availability of life-saving medicines and contributing to a healthier and more sustainable future for all.