Market Reports

Traceability: the backbone of the pharmaceutical supply chain

The pharmaceutical industry is one in which speed and quality are essential ingredients to a successful business. The proper software ensures suppliers become a force to help, not hinder, these factors, explains Andrew Bray, Managing Director, K3

The increasing power of single-cell omics: changing the future of medicine

Advances in the single-cell genomic analysis of cells and tissues, including the required computational methods, have now put systematic, high-resolution and comprehensive reference maps of all human cells within our reach. Paradigm4's Marilyn Matz, CEO and cofounder, and Dr Zachary Pitluk, VP of Life Sciences and Healthcare, report

Drug dose delivery development, manufacturing and commercialisation trends: part II

In the wake of patient-centricity in the pharmaceutical industry, drug delivery technologies have emerged as a central driver of therapeutic and patient success. Dr Kevin Robinson went online with Manuel Leal, Business Development Director, Idifarma, Steve Rode, Manager Business Development, Capsules and Health Ingredients, Lonza, and John Ross, President, Mayne Pharma US/Metrics Contract Services, to find out more

Technology to transform the capture and processing of drug safety data

The ultimate goal of pharmacovigilance is to prevent adverse drug reactions, thus maximising the benefit:risk ratio for as many patients as possible, reports Dr Andrew Rut, CEO and founder, MyMeds&Me

Navigating the sea change of pharmaceutical outsourcing: part II

After what has oft-been described as an unprecedented period of turbulence in almost every aspect of our everyday lives, Dr Kevin Robinson sat down with experts from a number of pharmaceutical contract development and manufacturing organisations (CDMOs) to discuss how the events of the past year have affected the activity and outlook of the industry’s outsourcing sector

Real-time monitoring of pharmaceutical coatings by optical coherence tomography (OCT)

The coating process is the last step of tablet production and thus influences some of the critical quality attributes (CQAs) of these oral solid dosage forms. RCPE's Stephan Sacher, Senior scientist, Process and Manufacturing Science, Matthias Wolfgang, Scientist, Process and Manufacturing Science, Anna Peter, Scientist, Process and Manufacturing Science, Sandra Stranzinger, Senior scientist, Advanced Products and Delivery, and Johannes Khinast, CEO and Scientific Director, explain

Moulded glass vials secure COVID-19 vaccine supply

Although different materials have been trialled and tested, glass remains the most widely used type of primary container for parenteral drug products, writes Dr Jingwei Zhang, R&D Director, SGD Pharma

Immunotherapy: antibody drug conjugates from a small molecule perspective

Immunotherapies such as ADCs deliver a more targeted treatment against cancer that improves the quality of life for the patient compared with traditional chemotherapies, write Maurits Janssen, Senior Director, Strategic Business Development, and Bernhard Stump, Associate Director, Head of Process Development Bioconjugates, Lonza Pharma & Biotech

API sourcing: what to look for in a supplier

Jonathan Knight, Director of Market Intelligence and New Technologies at Cambrex, presents an overview of the API sourcing marketplace, summarising the factors that need to be considered when choosing an API supplier in the light of recent global market, political and economic developments

From the lab to the last mile: optimising the pharma cold chain (part I)

With more than 40 COVID-19 vaccines in human testing worldwide and an expected 14 billion vaccines needed to facilitate a global vaccination, the stakes are high when it comes to safe storage and distribution. Dr Kevin Robinson recently caught up with Stirling Ultracold’s CEO, Dusty Tenney, and Robin Grimwood, President and COO of Infinity Biologix, to discuss the criticality of ULT storage as we approach a vaccine delivery date

Model-based optimisation of mixed solvent systems for spray drying

Spray drying is a common and effective approach to enhance the bioavailability of low-solubility small molecules. As the process requires intimate knowledge of aspects such as droplet trajectories, in this article Jonathan L. Cape, Kimberly B. Shepard and Michael M. Morgen, from Lonza Pharma & Biotech, examine different approaches to spray drying and ways to optimise drug production and quality

Developing innovative antivirals for novel viruses

Since the emergence of COVID-19, researchers worldwide have striven to study and overcome this new disease and the novel coronavirus (SARS-CoV-2) that causes it. To achieve this, we will probably need both vaccines and antiviral drugs, report Zamas Lam, Senior Vice President of Preclinical Development, and John Kolman, Vice President of Translational Medicine, QPS

Scaling-up the pharmaceutical supply chain with digitisation: part I

If there are issues with any vaccine, the traditional recall process, which is highly dependent on manual and paper-based processes — and provides no insight in terms of where the product ends up — is not up to the task. It is simply too slow and ill-informed to combat the fallout!

Cleanroom Conference and Manufacturing Chemist Live 2020 to go virtual

The virtual event taking place on 10-11 November 2020 will provide delegates with full access to the Manufacturing Chemist Live, Cleanroom UK, India and Singapore content and exhibitors

Transporting the COVID-19 vaccine around the world: a global problem

Elisabeth Vachette, Head of Product Management for Bags/Mixing/Tanks at Sartorius Stedim Biotech, discusses the challenges associated with distributing a vaccine to the global population with Dr Kevin Robinson

Manufacturing pressure accelerates move to fully formulated film coatings

Why now is the right time to change to a leaner system, explains Colorcon's Dr Jason Teckoe, Technical Director, EMEA

Small test efforts for large production facilities

Sanofi uses filling and closing machines from Syntegon Technology to determine the ideal manufacturing parameters for the development and lifecycle management of its products, explains Sebastian Lauterbach, Area Sales Manager, Syntegon Technology

Cleanroom Conference and Manufacturing Chemist Live events set to go ahead

The co-located events will go ahead in October with new safety measures in place, after being postponed from their original date at the start of summer due to COVID-19

Delivering success for inhaled drug development programmes

No two inhaled drug development programmes will have exactly the same characteristics or drivers; so, to ensure the greatest chance of success, it is important not to be unduly influenced by previous programme, or have a technology bias towards a single platform

Next-generation rapid transfer systems for the biopharmaceutical industry

The safe manufacture of pharmaceutical drugs requires perfectly sterile and particle-free environments. A rapid transfer port, which comprises double containment doors that are integrated into an isolator, is a system that allows the safe transfer of substances used in drug development, such as active pharmaceutical ingredients or vaccines

Overcoming the excipient challenge with a multifunctional filler-binder

Dr Maj-Britt Cepok, Head of Business Development Pharma at BENEO, talks to Dr Kevin Robinson about trends in excipients and explains why the right filler-binder can make all the difference

Isolator transfer design for ATMP products

A challenge posed by the increase of closed systems is the transfer of semi-finished products without losing the aseptic conditions required by regulations. A new study has tested a transfer system aiming to offer biocontainment without losing cell viability of ATMP products

Enhancing clinical trial supply with JTM: part II

In a constantly changing world, the pharmaceutical industry is having to adopt its practices to serve the needs of a rapidly growing and ageing population and develop innovative personalised medicines. Almac has responded to these demands with a Just-in-Time Manufacturing solution that fulfils the requirements of a high value, time sensitive clinical supply chain. Dr Kevin Robinson spoke to Natalie Balanovsky, Just-in-Time Manufacturing Solutions Manager, and Mark Rohlfing, Vice President of Operations, to find out more

Next-generation pharmaceutical spray drying

Lonza's Kimberly B. Shepard, Associate Principal Engineer, and Michael M. Morgen, Associate Director, R&D, discuss mechanistic process development with high-performance polymers for bioavailability enhancement

Trending Articles

  1. You need to be a subscriber to read this article.
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    How CRDMOs are shaping the next generation of antibody-drug conjugates To explore how CRDMOs are leading innovation in ADC development, Dr Kevin Robinson spoke with Srivats Rajagopal, Senior Director, Cell and Protein Sciences, Biology Solutions at Aragen Life Sciences, about key technological advancements and evolving partnership models that are redefining what it means to outsource in this space
  2. NICE recommends enfortumab vedotin with KEYTRUDA for adults in England/Wales with untreated metastatic urothelial cancer The results from the Phase III study EV-302/KN-A39 showed nearly a doubling of survival rates in patients compared with those who received platinum-based chemotherapy, which is the current standard of care in the UK
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    Start with the end in mind: the role of materials control in early CMC strategy for cell therapies Cell and gene therapy products are complex in their design, nature and mode of action. Because of this, the road to market can be a challenging one; littered with variables and failures, what might have been a valuable treatment often fails to reach much-in-need patients
  4. Freeze drying ADCs: points to consider for industrial applications As antibody-drug conjugates gain momentum in the pharmaceutical industry, manufacturers are increasingly looking to implement safe and effective process trains to produce them. Lyophilisation experts at GEA Pharma & Healthcare assess some of the most critical challenges and how to overcome them
  5. Rare diseases: understanding the patient journey In the shadow of Rare Disease Day on 28 February 2019, Dr Kevin Robinson met with Zizi Imatorbhebhe, Senior Director of Strategic Development and Head of PAREXEL’s Rare Disease Center of Excellence (RDCE), to discuss the future of rare disease research

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