Market Reports

Distributed control system reduces downtime for pharmaceutical manufacturer

In this case study, Rockwell Automation describes how Mallinckrodt Pharmaceuticals was able to streamline production and pinpoint potential bottlenecks by implementing a virtualised control system architecture

Flexibility through standardisation

The global pharmaceutical industry is going through a significant transformation, shifting from blockbuster drugs to personalised medicines based on biotechnology and genomics

There’s more than one way to produce pharmaceutical water

Bosch Packaging’s Susanne Handrick and Nils Ern examine the potential of cold membrane processes for the production of pharmaceutical water for injection

Winner of the Nobel Prize in Physiology or Medicine

William Kaelin Jr, Sir Peter Ratcliffe, and Gregg Semenza have won the Nobel Prize for Physiology or Medicine 2019 for their discoveries of how cells sense and adapt to oxygen availability

Medical cannabis made in Italy

Dr Fabio Di Francesco, a compounding pharmacist based in Rome, describes how cannabis is used in various dosage forms and the challenges ahead

Almac FAST: Continuous flow chemistry with assisted synthesis technology

Flow assisted synthesis technology (FAST) is a unique flow chemistry platform for continuous production of chemicals when batch-based processes fail to deliver the required quality of product

Peak identification by LC/MS: Automation versus analyst

High pressure liquid chromatography/mass spectrometry (LC/MS) is an important technique that facilitates the correct and accurate identification of impurities in pharmaceutical products and intermediates

Testing the limits of dosage production with continuous direct compression technology

GEA’s Dr James Holman, Head of New Development and Innovation, Pharma, discusses the process robustness and operational considerations of the company’s CDC 50 platform during a 120-hour trial run

Beximco Pharma: The Bangladeshi company connecting with the US

COO Rabbur Reza talks about the strategy behind approaching pharmaceutical manufacturing from an emerging market

Addressing the need for cost-effective vaccine manufacturing

Process intensification and integrated continuous bioprocessing are two approaches that can be used to achieve cost-effective, local production of high-quality biologic products. Tania Pereira-Chilima, Product Manager at Univercells, explains

Future market dynamics and opportunities in immuno-oncology

Long-term survival, tumour-agnostic effects and the potential for cure in a fraction of patients are key catalysts driving the explosion of research and recent approvals in IO. Dr Kevin Robinson recently caught up with SmartAnalyst’s Nidhi Dhingra and Jaideep V. Thottassery to delve a little deeper

A microfluidic approach to production of alginate beads for cell encapsulation

Gurinder Vinner, Material Scientist at Dolomite Microfluidics, discusses the benefits of continuous microfluidic production for the encapsulation of mammalian cells with no loss of viability

The case for single-use architecture in pharma

Billy Sisk, Life Sciences Industry Manager, EMEA, at Rockwell Automation recently contributed to the free downloadable e-book, the <i>Big Book of Biotech</i>, alongside input from GSK, Merck, ZeClinics and others. Here, for readers of <i>Manufacturing Chemist</i>, he picks up his topic of single-use facilities

Case Study: Phase I to commercial in 18 months

Gabor Heltovics, Druggability Technologies CEO, talks about using Quotient Sciences to progress and scale-up an improved pain relief drug formulation

Manufacturing misconceptions: The difficulties of tackling big data analysis

The advent of Industry 4.0 offers huge potential to explore new and exciting changes to the manufacturing floor, comments Dirk Ortloff, Department Manager, camLine

Guide to wash-in-place process in horizontal mixing systems

Modular solutions are proven to reliably fulfil any industry-specific requirements in the pharmaceutical, food, cosmetics, and chemical industries. Sebastian Steinkamp of Lödige provides a step-by-step guide to effective cleaning

Stainless steel products in contemporary bioprocessing

ASEPCO's Mark Embury on the shift from stainless steel to single-use systems in the pharmaceutical manufacturing sector

A rules-based approach to labelling and artwork management: Part I

Many organisations today are experiencing unprecedented demands from regulatory authorities and consumers alike for product labelling to be made clearer and more informative, says Graham Francis, Channel Marketing Manager, Kallik

A new approach to molecular imaging in cancer patients

A variety of different imaging approaches, spanning molecular to whole-body scans, have contributed greatly to our understanding of the conditions required for an effective anticancer immune response, reports Ian Wilson, CEO, ImaginAb

Unlocking R&D potential with equipment expertise

Worldwide, pharmaceutical manufacturers face a daunting challenge: that of reconciling ever-higher cost pressures with increased quality requirements

Taking a multifaceted approach to combatting superbugs

Paul Chapman, Partner at Marks & Clerk LLP, takes a look at research underway for testing a compound on Gram-negative bacteria known for being the most difficult to treat of all infections

Seal selection for pump optimisation

Process containment and reducing the risk of product contamination are key requisites for pharmaceutical production equipment. Yet the industry is notoriously averse to change when it comes to the selection of mechanical seals and seal materials, says John Smiddy, European Business Development and Technical Support Director for AESSEAL

Integrated tools for upstream process intensification: Part I

Changes to bioprocessing methodologies are driven by the need for increased speed, a lower cost of goods and greater flexibility, writes Gerben Zijlstra, Global Technology Consultant at Sartorius Stedim Biotech

The future of supply chain management in pharmaceuticals

Global regulations and local legislation have made serialisation in the pharmaceutical industry standard practice. And, although serialisation is now commonplace, the supply chain is still beset with potential issues such as counterfeit products, says Andreas Bechthold, General Manager, Mettler-Toledo

Trending Articles

  1. The new regulatory world for medical devices Establishing an effective compliance strategy now ahead of the 2022 IVDR legislation is critical — because there’s more to come
  2. Recombinant versus synthetic peptide synthesis: the perks and drawbacks Since the introduction of novel peptide drugs into the market, the demand for polypeptide manufacturing has significantly increased, reports Dr Philipp Markolin
  3. Peak identification by LC/MS: Automation versus analyst High pressure liquid chromatography/mass spectrometry (LC/MS) is an important technique that facilitates the correct and accurate identification of impurities in pharmaceutical products and intermediates
  4. Reading and understanding vendor-supplied tablet drawings Understanding the tablet drawings supplied by tooling vendors is a meaningful way to learn more about your product, reports John Norman, Technical Service Representative, Natoli Engineering Company
  5. Model-based optimisation of mixed solvent systems for spray drying Spray drying is a common and effective approach to enhance the bioavailability of low-solubility small molecules. As the process requires intimate knowledge of aspects such as droplet trajectories, in this article Jonathan L. Cape, Kimberly B. Shepard and Michael M. Morgen, from Lonza Pharma & Biotech, examine different approaches to spray drying and ways to optimise drug production and quality