Alkermes, through the merger with Elan Drug Technologies, to become Alkermes plc, has been developing and manufacturing commercial scale solid oral dosage products for more than 40 years. This case study demonstrates a large pharmaceutical contract manufacturing engagement in which there has been five years trouble-free supply with OTIF (On-Time-In-Full) consistently >95%.<br> Process and product improvement initiatives were also delivered, which enabled significant capacity and yield improvements. These improvements resulted in significant cost savings for our partner.